Same safety, fewer characters
A default Nano ID is 21 characters from a 64-symbol alphabet, giving 126 bits of entropy - slightly more than a version 4 UUID's 122, in 21 characters instead of 36. The saving comes from the encoding rather than from any compromise in randomness. A UUID writes 128 bits as hexadecimal, which packs only 4 bits per character, and then adds four hyphens. Nano ID uses a 64-symbol alphabet at 6 bits per character and no separators.
Where that matters is anywhere identifiers are visible or repeated. A 40% shorter identifier makes URLs more manageable, fits more comfortably in fixed-width UI, and reduces bytes across every index and log line at scale. For an identifier a user might read aloud or type, the difference is more than cosmetic.